Objective: To explore the value of receiving personalized comprehensive care for patients with severe pneumonia. Methods: 73 patients with severe pneumonia who visited the clinic from February 2020 to February 2023 were included in this study. The patients were randomly grouped into Group A and Group B. Group A received personalized comprehensive care whereas Group B received conventional care. The value of care was compared. Results: The duration of mechanical ventilation time, the time taken for fever and dyspnea relief, and the hospitalization time of Group A were shorter than those in Group B (P < 0.05). The blood gas indexes such as PaO2, PaCO2, and blood pH of Group A were better than those of Group B (P < 0.05). The pulmonary function indexes such as peak expiratory flow (PEF), forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV1) of Group A were better than those of Group B, P < 0.05. Moreover, the patients in Group A were generally more satisfied with the care given compared to the patients in Group B (P < 0.05). Conclusion: Personalized comprehensive care improves blood gas indexes, enhances lung function, accelerates the relief of symptoms, and also enhances patient satisfaction in severe pneumonia patients.