Objective: To study the methods and effects of health education during pregnancy in the clinical nursing work of obstetrics and gynecology. Methods: Between January 2022 and January 2024 in the hospital 140 cases of pregnant women, can be divided into two groups, an observation group and a control group, respectively, between groups of 70 people. The observation group was given health pregnancy education, while the control group was given routine nursing. Results: After intervention compared two groups of natural childbirth, postpartum breast feeding rate and postpartum bleeding, observation group is better than the control group. The results of the two groups have statistical significance (P < 0.05). Conclusion: The application of health education during pregnancy in the nursing of obstetrics and gynecology has a good effect, can be widely welcomed and has clinical value.