A Case Report of Disseminated Nocardiosis

© 2024 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Download PDF

Cite

XML

HTML

Abstract

Objective: To summarize the clinical characteristics and treatment plan for a case of disseminated nocardiosis. Methods: The study summarized the clinical characteristics and treatment plan for a case of disseminated nocardiosis. Results: The primary symptoms of the patient included high fever and multiple enlarged lymph nodes. Chest computed tomography revealed a shadow of nodules in the upper lobe of the left lung, multiple nodules, and pleural effusion in both lungs. Additionally, bilateral blood cultures indicated the presence of Nocardia terpenica. The final diagnosis was disseminated Nocardia sp. infection. Upon admission, anti-infective treatment was initiated with sulfamethoxazole and linezolid. Conclusion: In patients with normal immune function, disseminated nocardiosis may present as high fever with lymph node enlargement, necessitating differentiation from lymphoma. This study reports on the diagnosis and treatment plan of a case of disseminated nocardiosis to enhance understanding and clinical management of this disease.

References

Han Y, Cheng M, Li Z, et al., 2024, Clinical Characteristics and Drug Resistance of Nocardia in Henan, China, 2017–2023. Ann Clin Microbiol Antimicrob, 23(1): 23. https://doi.org/10.1186/s12941-024-00677-4

Wang C, Sun Q, Yan J, et al., 2023, The Species Distribution and Antimicrobial Resistance Profiles of Nocardia Species in China: A Systematic Review and Meta-Analysis. PLoS Negl Trop Dis, 17(7): e0011432. https://doi.org/10.1371/journal.pntd.0011432

Hoshino Y, Watanabe K, Iida S, et al., 2007, Nocardia terpenica sp. nov., Isolated from Japanese Patients with Nocardiosis. International Journal of Systematic and Evolutionary Microbiology, 57(7): 1456–1460. https://doi.org/10.1099/ijs.0.64695-0

Gupta S, Grant LM, Powers HR, et al., 2023, Invasive Nocardia Infections across Distinct Geographic Regions, United States. Emerg Infect Dis, 29(12): 2417–2425. https://doi.org/10.3201/eid2912.230673

Lee HN, Do KH, Kim EY, et al., 2024, Comparative Analysis of CT Findings and Clinical Outcomes in Adult Patients With Disseminated and Localized Pulmonary Nocardiosis. J Korean Med Sci, 39(11): e107. https://doi.org/10.3346/jkms.2024.39.e107

Soueges S, Bouiller K, Botelho-Nevers E, et al., 2022, Prognosis and Factors Associated with Disseminated Nocardiosis: A Ten-Year Multicenter Study. J Infect, 85(2): 130–136. https://doi.org/10.1016/j.jinf.2022.05.029

Presant CA, Wiernik PH, Serpick AA, 1973, Factors Affecting Survival in Nocardiosis. Am Rev Respir Dis, 108(6): 1444–1448. https://doi.org/10.1164/arrd.1973.108.6.1444

Liu P, Wang Z, Jian Z, et al., 2023, The Clinical Characteristic and Management of Patients with Nocardiosis in a Tertiary Hospital in China. J Microbiol Biotechnol, 33(5): 574–581. https://doi.org/10.4014/jmb.2209.09034

Saubolle MA, Sussland D, 2003, Nocardiosis: Review of Clinical and Laboratory Experience. J Clin Microbiol, 41(10): 4497–4501. https://doi.org/10.1128/JCM.41.10.4497-4501.2003

Margalit I, Lebeaux D, Tishler O, et al., 2021, How Do I Manage Nocardiosis? Clin Microbiol Infect, 27(4): 550–558. https://doi.org/10.1016/j.cmi.2020.12.019

Balachandar A, Zhabokritsky A, Matukas LM, 2020, Disseminated Nocardiosis with Multisite Involvement in An Immunocompetent Patient. CMAJ, 192(33): E956–E959. https://doi.org/10.1503/cmaj.200153

Previous article in this issue

Next article in this issue