Objective: To explore the value of bundled nursing interventions based on empowerment theory in the care of patients with indwelling urinary catheters. Methods: Forty-two patients with indwelling urinary catheters, admitted from June 2022 to June 2023, were sampled and randomly divided using a random number table. Group A received bundled nursing care based on empowerment theory, while Group B received standard care. The differences in catheterization duration, unplanned extubation rate, emotional scores, quality of life scores, and adverse events were compared. Results: Group A had a shorter catheterization duration and a lower rate of unplanned extubation than Group B, with P < 0.05. Anxiety (SAS) and depression (SDS) scores were lower in Group A than in Group B, with P < 0.05, and the quality of life (SF-36) scores were higher in Group A than in Group B, with P < 0.05. The adverse event rate for Group A was also lower than that for Group B, with P < 0.05. Conclusion: Patients with indwelling urinary catheters who received bundled nursing care based on empowerment theory experienced improved emotional stability, optimized quality of life, fewer unplanned extubation events, and the intervention was highly effective and feasible.