Objective: To analyze the effects of a coordinated intervention plan combining oral health and self-care on the oral health, self-care ability, and hospitalization satisfaction of colorectal cancer patients post-chemotherapy. Methods: A total of 106 patients undergoing postoperative chemotherapy for colorectal cancer from October 2022 to August 2023 were randomly divided into two groups. Both groups received routine nursing care, while the intervention group also received a coordinated intervention program. The effectiveness of the intervention was evaluated using the oral odor score, Beck oral rating scale, self-care ability scale, and patient hospitalization satisfaction scale. Data was collected before the intervention, and on the 7th and 14th days after the intervention. Results: No significant differences were found between the two groups before the intervention (P > 0.05). After the intervention, the intervention group showed significant improvements in Beck oral score, dry mouth, and bad breath scores (P < 0.05), compared to the control group. There was no significant difference in oral pH between groups (P > 0.05). Self-care ability improved significantly in the intervention group (P < 0.05). Independent sample t-tests revealed that the intervention group had significant improvements in satisfaction with medical care, including doctors’ and nurses’ professional skills and humanistic care (P < 0.05). No significant differences were found in waiting time and hospital environment (P > 0.05). Conclusion: The coordinated intervention plan combining oral health and self-care for colorectal cancer patients post-chemotherapy significantly improves oral health, self-care ability, and hospitalization satisfaction. This approach, integrating traditional Chinese and Western medicine, has great potential for clinical application.