This study summarizes the nursing experience of a patient with active Crohn’s disease in the acute stage, complicated by small bowel obstruction. Key aspects of nursing include psychological response guidance during the active phase of Crohn’s disease, support before and after various gastroenteroscopy procedures and related reports, and self-monitoring guidance for symptoms such as intestinal obstruction combined with endoscopic mucosal ulcers. Using the 5A nursing model, nursing staff assessed the patient’s needs, provided targeted nursing recommendations in stages, implemented health behavior strategies, and offered continuous nursing care, including positive support for sexual health beliefs. These interventions helped the patient overcome psychological challenges, such as resistance to indwelling gastric tubes, and adopt healthy behaviors. After six weeks of follow-up through phone and WeChat consultations, the patient demonstrated significant improvement, including a weight gain of 15 kg. Various test results indicated normalized nutritional and inflammatory indexes, and the Crohn’s Disease Activity Index decreased by ≥ 70 points. In conclusion, establishing a nursing team and applying the 5A nursing model to formulate detailed nursing diagnoses and interventions can significantly improve outcomes for patients with active Crohn’s disease complicated by small intestinal obstruction.