Objective: To analyze the effect of atorvastatin combined with trimetazidine in the treatment of elderly coronary artery disease and the effect on patients’ cardiac function. Methods: 60 cases of elderly coronary artery disease patients were divided into 2 groups by randomization method, and all of them received conventional symptomatic treatment, while atorvastatin was added to the control group and trimetazidine was combined with atorvastatin in the observation group, and the clinical indexes were compared. Results: After treatment, the angina attack, cardiac function indexes, and inflammatory factor levels of the observation group were better than those of the control group (P < 0.05), and the differences in adverse reactions between the two groups were not significant (P > 0.05). Conclusion: Combined treatment of coronary heart disease in the elderly with atorvastatin and trimetazidine can positively reduce angina symptoms, improve cardiac function, and reduce inflammatory reactions, and the effect is definite.