Objective: To investigate the effect of continuous double-lumen irrigation drainage at constant temperature on the control of abdominal infection after surgery, providing a reference for clinical treatment. Methods: From December 2022 to August 2023, 100 patients with abdominal infections after surgery were selected from Wendeng People’s Hospital in Weihai. They were randomly divided into a control group (50 cases, using conventional single-hole rubber irrigation drainage) and an observation group (50 cases, using continuous double-lumen irrigation drainage at constant temperature). The inflammatory and immune indicators of the two groups were compared after different interventions, and the specific conditions of abdominal infection were statistically analyzed. Results: There was no significant difference in inflammatory indicators between the two groups before intervention (P > 0.05). After the intervention, the inflammatory indicators of the observation group were significantly lower (P < 0.05). There was no significant difference in immune function indicators between the two groups before intervention (P > 0.05). After intervention, the immune function indicators of the observation group showed significant improvement (P < 0.05). The control of abdominal infection in the observation group was better than in the control group (P < 0.05). Conclusion: Continuous double-lumen irrigation drainage at constant temperature has a better effect on controlling abdominal infection after surgery, improving the infection condition, and enhancing the immune function of patients.