Clinical Efficacy of Pentoxifylline Combined with Thioctic Acid in the Treatment of Painful Diabetic Peripheral Neuropathy

© 2024 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To observe the efficacy of pentoxifylline + thioctic acid in the treatment of patients with painful diabetic peripheral neuropathy (PDPN). Methods: 70 patients with PDPN admitted from October 2019 to October 2022 were selected and randomly grouped, with pentoxifylline + thioctic acid treatment in Group A and thioctic acid treatment in Group B, and the treatment efficacy was compared. Results: The treatment efficacy in Group A was higher than that of Group B, P < 0.05; the points of each symptom of PDPN in Group A were lower than that of Group B, P < 0.05; the C-reactive protein and electromyography indexes of PDPN patients in Group A were better than that of Group B, P < 0.05. Conclusion: PDPN patients treated with pentoxifylline + thioctic acid can optimize nerve function, inhibit inflammation progression, and reduce PDPN symptoms, which is an efficient and feasible treatment option.

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