Objective: To explore the application of external application of Traditional Chinese Medicine (TCM) hot compress package combined with Kinesio Taping in postoperative nursing of total knee arthroplasty. Methods: Ninety patients with severe knee osteoarthritis who underwent total knee arthroplasty in our department from January to December 2022 were randomly divided into two groups using a random number table method: one group was named the conventional group (n=45), which received the standard orthopedic nursing process throughout, including basic pain management, incision care, and functional exercise guidance; the other group was defined as the experimental group (n=45), which, in addition to the conventional nursing framework, incorporated the local transdermal drug delivery technique of TCM hot compress package and the biomechanical correction scheme of Kinesio Taping for collaborative intervention. Finally, the differences in postoperative resting/active pain scores (VAS) of the affected limb and satisfaction with nursing services between the two groups were compared using quantitative assessment tools. Results: The satisfaction with nursing care in the conventional group was significantly lower than that in the experimental group (P < 0.05); the VAS score after nursing in the conventional group was significantly higher than that in the experimental group (P < 0.05). Conclusion: The application of external application of TCM hot compress package combined with Kinesio Taping in postoperative nursing of total knee arthroplasty has a definite effect, reducing pain and improving patient satisfaction with nursing services.