Study on the Correlation between Irisin Expression and the Healing of Diabetic Skin Injury

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

A diabetic skin ulcer model was established by combining streptozotocin (STZ) administration with full-thickness skin defect surgery to evaluate the changes in irisin levels during the healing process. The experiment was divided into 2 groups, with 6 mice in each group: the normal control group and the diabetic skin injury group. Compared with the normal group, the model injury group showed a significant increase in blood glucose (p < 0.001), a significant decrease in healing rate (p < 0.001), and a significant decrease in irisin levels (p < 0.001) after 14 days. Irisin levels were positively correlated with blood glucose and positively correlated with wound healing rate. In conclusion, irisin may be a potential therapeutic target for the treatment of diabetic skin injury.

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