Objective: To observe the application effect of risk management in the nursing work of fever clinics, especially its effect on improving nursing satisfaction and the work quality of nursing staff, as well as reducing the incidence of nursing risk events, and to provide a scientific reference for future clinical research and practice. Methods: This study adopted a retrospective approach, fixing the research period from December 2024 to August 2025. A total of 110 patients admitted to the fever clinic of our hospital were selected as the research objects and divided into two groups (the control group and the experimental group) using the random number table method. Each group had 55 patients. Then, differentiated nursing strategies were implemented for the two groups. Both the control group and the experimental group received routine nursing. The difference was that the experimental group was additionally given risk management measures on the basis of routine nursing. After 7 days of intervention, the nursing satisfaction rate, nursing quality, cognitive score of fever clinic risks, nursing error rate, complaint rate, and incidence of risk events were compared and analyzed between the two groups. Results: The nursing satisfaction score, nursing complaint rate, incidence of nursing risk events, nursing error rate, nursing quality score, and cognitive score of fever clinic risks in the experimental group were significantly better than those in the control group. The differences were statistically significant (P < 0.05). Conclusion: Risk management has a significant application effect in the nursing work of fever clinics, playing a positive role for both patients and nursing staff. It is an effective measure to comprehensively improve nursing quality and an important means to greatly reduce the incidence of nursing risk events, thus having high clinical promotion value.