In the new era, curriculum ideological and political education has become one of the core approaches for higher education to implement the fundamental task of moral education. Obstetrics and gynecology nursing is a professional basic course for medical nursing majors, featuring professionalism, humanism, and sociality, which has a natural fit with the integration of curriculum ideological and political education. Based on the professional characteristics of obstetrics and gynecology nursing teaching, this paper constructs a “six-in-one” integration path from six dimensions: integration goals, element excavation, content penetration, method innovation, evaluation system, and teacher team construction. It provides a reference for cultivating obstetrics and gynecology nursing talents with both exquisite professional skills and noble professional literacy.