Objective: To analyze the burden of caregivers of CHF patients in the current environment, to explore the related burden and influencing factors of caring for patients with chronic heart failure, and to explore the impact of filial piety values on the burden of caring for patients. Methods: 192 caregivers of CHF patients in the hospital were selected as the main objects of this study. The main method was convenient sampling. Through a questionnaire survey of 192 CHF patients’ caregivers, a unified investigation was conducted from the aspects of patient'’s general condition, objective burden, anxiety and depression degree and relationship quality, etc. The structural equation model was constructed and adjusted by analyzing data entry and variable correlation. Finally, path analysis was used to conduct inferential research on the direct and indirect influencing factors of control burden. Results: More than half of the patients’ caregivers had a caregiving burden, and the practical caregiving dimension had the highest score. The total effect values of patient-related factors, including anxiety degree, number of concomitant diseases and half-year readmission rate, were 0.36, 0.31 and 0.20, respectively (P < 0.05). The total effect values of filial piety, anxiety degree, average care time and understanding degree of disease directly derived from the caregivers themselves were -0.38, 0.29, 0.29 and -0.23, respectively (P < 0.05). In addition, the influence of filial piety values on the caregiver burden was more obvious, and the direct effect value of the value was -0.41 (P < 0.001). Conclusion: Most caregivers of CHF patients have a certain objective burden of care, and there are many factors that affect it, among which the degree of filial piety value is the most important. This finding provides a clear goal for caregivers to develop measures to improve the caregiver burden.