The purpose of this study is to investigate the effectiveness of the “expiration manager” mini program in managing the validity of ward items. The program was used to manage frequently and infrequently used consumables by setting up an automatic reminder function. The item failure rate and the time required for nurses to conduct counts over 6 months before and after implementation were compared, as well as evaluated system availability using the System Usability scale (SUS). Results showed that after implementing the mini program, both the item failure rate and non-recognition rate significantly decreased (P < 0.05), while the inspection pass rate significantly increased (P < 0.05), and the monthly inventory time was reduced (P < 0.05). The SUS evaluation yielded a total score of 74.38 ± 11.73, with learnability at 80.21 ± 20.27 and availability at 72.92 ± 11.18, all indicating good user acceptance. In conclusion, the “expiration manager” mini program can effectively improve the efficiency of item expiration management, reduce the risk of expiration, and save inspection time, thereby demonstrating high user acceptance and promising potential for wider adoption.