This study aimed to explore the application effect of the medical and nursing integration working mode in children with inguinal hernia undergoing laparoscopic surgery and to provide a basis for its clinical promotion. A total of 70 children with inguinal hernia admitted to our hospital from July 2023 to June 2024 and treated with laparoscopic surgery were selected as study subjects and randomly divided into an observation group and a control group, with 35 cases in each. Both groups received routine nursing care, while the observation group additionally adopted the integrated medical and nursing working mode, including systematic health education, psychological interventions, and postoperative follow-up from admission to discharge. The anxiety and depression scores of the two groups before and after surgery, medical compliance index, and incidence of complications during hospitalization were compared. Results showed that the preoperative anxiety scores of the observation and control groups were (14.01 ± 1.07) and (14.62 ± 2.31), respectively, with no statistically significant difference (P > 0.05); however, postoperative anxiety scores were significantly lower in the observation group (4.01 ± 0.77) compared to the control group (6.62 ± 0.31) (P < 0.05). Similarly, preoperative depression scores were (15.11 ± 1.22) in the observation group and (15.41 ± 2.01) in the control group (P > 0.05), but postoperative depression scores were significantly reduced in the observation group (4.24 ± 0.61) compared to the control group (7.12 ± 0.54) (P < 0.05). After intervention, the medical compliance behavior index in the observation group was (83.31 ± 5.92), significantly higher than (75.34 ± 6.73) in the control group (P < 0.05). Regarding postoperative complications, only 1 case (2.86%) occurred in the observation group, while 8 cases (22.86%) were reported in the control group, showing a statistically significant difference (P < 0.05). In conclusion, the medical and nursing integration working mode effectively improves the perioperative psychological state of children, enhances medical compliance, reduces postoperative complications, and is worthy of widespread clinical application.