Objective: To explore the clinical efficacy of traditional Chinese medicine Fuzheng Quxie tea drinking package in the treatment of Zhengxu Xielian type cancer. Methods: In this study, 50 cases of Zhengxu Xielian type cancer admitted to our hospital from January 2020 to December 2021 were selected. They were divided into a control group (n = 25) and a treatment group (n = 25) according to the random number table method. The control group received conventional symptomatic treatment plus adjuvant therapy for cancer while the treatment group received traditional Chinese medicine Fuzheng Quxie tea drinking package plus conventional symptomatic treatment and adjuvant cancer therapy. Tumor marker indexes, quality of life scores, and fatigue scores before and after treatment were compared and analyzed between the two groups. Results: After treatment, the CEA, CA125, and NSE indexes in the treatment group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the quality of life scores of the treatment group were better, and the data between the two groups were statistically significant (P < 0.05). After treatment, the fatigue score of the observation group was significantly lower at 67.56 ± 4.69 compared to 110.59 ± 10.59 in the control group (t = 18.576, P < 0.05). Conclusion: The treatment of Zhengxu Xielian type cancer patients with traditional Chinese medicine Fuzheng Quxie tea drinking package can significantly reduce tumor marker indexes, improve patients’ quality of life, and reduce fatigue, which has clinical significance.