Objective: To explore the application effect of bundle management in the safe nursing of patients with autoimmune encephalitis. Methods: Seventy-five patients with autoimmune encephalitis who met the inclusion criteria in our hospital from January 2024 to June 2024 were randomly divided into two groups: an observation group of 39 patients and a control group of 36 patients. The control group received routine nursing care, while the observation group implemented a bundle management strategy based on routine nursing care. Safety nursing outcomes, clinical symptom improvement time, hospital stay, and neurologic function recovery were observed in both groups. Results: The incidence of adverse events in the observation group was 12.82%, significantly lower than the 33.33% in the control group, with a statistically significant difference (P < 0.05). There was no statistically significant difference in restraint usage and ICU transfer rates between the two groups (P > 0.05). The clinical symptom improvement time, hospital stay, and neurologic function recovery in the observation group were significantly better than those in the control group, with a statistically significant difference (P < 0.05). Conclusion: Through the bundle management model, effective connections can be ensured in various aspects of treatment and rehabilitation for patients with autoimmune encephalitis, providing patients with comprehensive and multi-level nursing services and improving their overall satisfaction and treatment effectiveness.