Objective: To analyze the preventive effect of traditional Chinese medicine sachets on influenza. Methods: A total of 100 subjects meeting the inclusion criteria were recruited in a certain area based on population characteristics (age, occupation, gender). The subjects were divided into a sachet group (50 cases) and a control group (50 cases). The sachet group was given traditional Chinese medicine sachets with epidemic prevention and infection prevention effects (recommended to carry along or sniff intermittently, at least 3 times a day, each time not less than 1 minute. Replace the sachet medicine after one month when the scent disappears, and continue to use for 2 months). The control group did not receive any intervention measures. After the experiment, subjects filled out a questionnaire and an efficacy evaluation form. Results: Comparing the baseline data of the two groups, there was no statistical significance (P > 0.05). Comparing the symptoms of colds between the two groups, there was no significant difference in nasal congestion, rhinorrhea, and fatigue symptoms between the two groups (P > 0.05). However, the possibility of fever in the sachet group was much lower than that in the control group (P < 0.05). Comparing the immunoglobulins (IgA, IgM, and IgG) of the two groups before and after intervention, it was found that before the intervention, P > 0.50; after the intervention, the immunoglobulin levels of both groups increased, and the increase in the sachet group was much higher than that in the control group (P < 0.05). Comparing the occurrence of side effects in the two groups, it was found that the incidence of allergies in the sachet group was 4.00%. Due to allergies, two subjects withdrew from the study halfway (P > 0.05). Conclusion: In influenza, wearing traditional Chinese medicine sachets can effectively prevent colds and reduce the incidence of colds, but those who are allergic to sachets should use them with caution.