With the development of the social economy and the continuous improvement of people’s living standards, the number of coronary heart disease patients is on the rise, even affecting some younger groups. When a patient’s coronary artery stenosis endangers their life, doctors usually recommend coronary artery stent surgery to effectively improve myocardial ischemia and prevent sudden death. After a successful operation, it is necessary to clarify the key points of clinical nursing and prevent complications. Starting from the situation after coronary heart disease stent implantation, this article analyzes the key points of clinical nursing and proposes specific strategies for preventing complications, aiming to improve the surgical effect and provide a reference for complication prevention activities.