Reviewing the Role of Oral Microbiota in Cognitive Impairment from Microbiota Homeostasis and Pathogenic Bacteria

© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Cognitive impairment is a common symptom of various neurodegenerative diseases. In recent years, an increasing body of research has focused on the relationship between oral microbiota and cognitive impairment. This review aims to explore the microbial homeostasis of oral microbiota and its interactions and mechanisms with the host, as well as the impact of specific pathogenic bacteria on cognitive function. By summarizing existing studies, this review aims to provide a theoretical basis for the pathogenesis, risk assessment, and early intervention and treatment strategies for cognitive impairment.

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