This study investigates the mental health challenges faced by international nursing students in the Philippines during a global health disruption like the COVID-19 pandemic, particularly focusing on symptoms of depression, anxiety, and stress (DAS). With the first incidence of global outbreak in the Philippines reported in 2020, the pandemic has intensified psychological distress among international students, who already struggle with sociocultural adjustment issues such as alienation and culture shock. The study aimed to determine the prevalence and contributing factors of DAS among this group. Using descriptive statistics and the DASS-21 tool, the research found that international nursing students exhibited alarmingly high levels of depression, anxiety, and stress. Pearson’s test of association was employed to explore relationships between DAS symptoms and demographic variables. Results highlighted key predictors of mental health distress, including age, gender, length of stay in the country, and sleep patterns. These findings address a significant gap in existing literature concerning international students’ mental health in the Philippines during pandemics. The study concludes by urging healthcare providers and policymakers to integrate these insights into emergency preparedness plans and educational reforms, emphasizing the importance of supporting the psychological well-being of international students during crises. Replication with additional variables is recommended for a more comprehensive understanding.