This study investigated the effect of hydrogen-rich atomic water on eye fatigue. The experimental results show that hydrogen-rich atomic water can reduce oxidative stress and inflammatory reaction in the eye, and has a significant improvement effect on myopia and visual fatigue, with high safety and no obvious adverse reactions. The results of myopia and visual fatigue improvement experiment showed that the prevalence of myopia in the control group was 15%, and the prevalence of myopia in the experimental group was 5%. The prevalence of myopia in the experimental group was significantly lower than that in the control group. The ocular symptoms of the experimental group were better than those of the control group in the improvement of fatigue, dry eyes, red blood stains and other symptoms. The patient satisfaction score of the experimental group was 95.5%, which was significantly higher than that of the control group. There were no adverse events such as allergic reactions or skin irritation in the experimental group and the control group during the whole experiment.