The data of the analytical estimation on the efficiency of providing safety control of the radio-electronic system are given. The review is based on the investigation of the information interaction of the radio-electronic system (RS) with monitoring subsystem. The problem of optimal safety operational subsystem control of the RS and the generalized criterion for the effectiveness of decision making by the control system of the RS are formulated. Analytical expressions that allow making the choice of optimal ratio between the safe and the most effective modes of the control system operation are obtained.