As China-US relations and COVID-19 situation are getting more and more serious, the cooperation between the Guangdong and Portuguese-speaking countries may also be affected. This article starts with the research on the cooperation mechanism and situation between China and Brazil under the Belt and Road Initiative. It uses SWOT to analyze Brazil's innovation advantages and shortcomings, the opportunities brought by scientific and technological cooperation and how to handle to the corresponding threats. This article attempts to propose areas and suggestions for the development of scientific and technological cooperation between the two sides.