This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip (SoC) functional safety and information security. It includes an introduction to the functions and information security of autonomous driving SoCs, as well as the main design strategies for the collaborative prevention and control mechanism of SoC functional safety and information security in autonomous driving. The research shows that in the field of autonomous driving, there is a close connection between the functional safety of SoCs and their information security. In the design of the safety collaborative protection mechanism, the overall collaborative protection architecture, SoC functional safety protection mechanism, information security protection mechanism, the workflow of the collaborative protection mechanism, and its strategies are all key design elements. It is hoped that this analysis can provide some references for the collaborative protection of SoC functional safety and information security in the field of autonomous driving, so as to improve the safety of autonomous driving technology and meet its practical application requirements.