The purpose of this article is to explore the design of compound interchange interweaving sections on expressways. During the research phase, based on the support of the literature research method, the classification and development of the interchange system, as well as the design forms of the compound interchange interweaving section, were analyzed. Subsequently, based on the case method, the design of the compound interchange interweaving section of the ShiWu and ShiBai expressways in Shiyan, Hubei Province, was discussed, and a design scheme and scheme comparison were proposed. It is hoped that this article can provide technical reference and ideas for China’s road and bridge engineering teams, ensuring that the design results can not only guarantee the normal passage of traffic on the North Intersection Expressway but also ensure the straight-line traffic capacity of the main highway under the background of dislocation intersection, achieving smooth and safe transitions between different expressways.