In the era of rapid development in digital media, cultural and creative design, as an important means of inheriting and disseminating regional culture, faces new opportunities and challenges. This paper takes Haikou Qilou as a case study to delve into the practical approaches of cultural and creative design in telling Chinese stories under the context of digital media. By analyzing the cultural connotations and values of Haikou Qilou and combining the characteristics of digital media, this paper proposes practical strategies in areas such as creative exploration, design expression, and promotion. The aim is to provide a reference for the inheritance and innovation of regional culture in the digital age, and to promote excellent traditional Chinese culture onto broader stages.