With the continuous deepening of China’s higher education system reform, universities have adopted a multi-campus model through mergers, reconstructions, and expansions, alleviating the constraints on their development and leading to a significant rise in infrastructure construction project procurement. Consequently, internal control and risk management in the procurement process under the multi-campus management model have garnered widespread attention. The bidding and procurement in the engineering field now face new risks and challenges. By analyzing factors such as the division of procurement management responsibilities and the connection of procedures across campuses, the complexity and variability of construction project procurement, and the characteristics of university construction project procurement, this paper proposes a risk prevention and control system for multi-campus engineering bidding and procurement under the principles of “centralized leadership, tiered management, and professional collaboration.