Selective internal radiation therapy using yttrium-90 has been used to treat hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and other malignant tumors that have spread to the liver locally. The authors used the bibliometric approach in response to the neoplasms, using the keyword “Yttrium 90 AND Liver Neoplasms” as a search parameter and then looked up pertinent English-language literature in the Web of Science core collection database’s self-built database through November 30, 2025. For statistical analysis and literature management, EndNote and Excel tools were utilized. In addition to co-citation and emergent keyword analysis of authors, VOSviewer and CiteSpace were utilized for social network and chronological order of countries, institutions, authors, and keywords. The aim of this study was to serve as a reference for future research by methodically sorting through the international research literature on Yttrium 90 treatment of liver neoplasms and summarizing the research status and hot trends in this field. In recent years, research focus has increasingly shifted toward high-quality, multi-center clinical trials that combine SIRT-targeted systemic therapy with hepatectomy following the descending stage. This approach is likely to remain a significant research trend in the field.