Research Progress on Malnutrition and Nutritional Intervention in Children with Leukemia During Chemotherapy

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Download PDF

Cite

XML

HTML

Abstract

This study systematically analyzed the primary causes of malnutrition in children with leukemia during chemotherapy, clarified the status of malnutrition and specific nutritional intervention measures, and comprehensively evaluated the research progress. The research indicates a shift from basic supportive care toward precision intervention strategies. Immunonutrition approaches, such as omega-3 fatty acid supplementation and probiotics for gut microbiota modulation, significantly mitigate chemotherapy-related side effects and enhance nutritional status. These targeted novel regimens demonstrate clear clinical advantages. The success of nutritional management depends on a multidisciplinary collaboration mechanism. The organic integration of innovative nutritional protocols with standard treatments from hematology, pediatrics, and nutrition departments significantly optimizes treatment outcomes and long-term quality of life for children with leukemia. This interdisciplinary synergy is reshaping contemporary medical models.

References

Mao Q, Mao XR, Li X, et al., 2024, Application of a Specialist Nurse-Led Nutrition Management Program in Children With Leukemia During Induction Remission Chemotherapy. Chinese Journal of Nursing, 59(23): 2900–2907.

Chen Y, Chen P, Zhang N, et al., 2024, Effects of Oral Nutritional Supplementation on Hematologic Complications During Induction Chemotherapy in Children With Acute Lymphoblastic Leukemia: Interim Results of a Randomized Controlled Trial. Journal of China Pediatric Blood and Cancer, 29(2): 103–108 + 122.

Bao QX, Cai JP, Zhou Q, et al., 2024, Analysis of Nutritional Status and Construction and Validation of a Visual Model for Predicting Malnutrition Risk in Children With Acute Leukemia. Maternal and Child Health Care of China, 39(23): 4670–4674.

Liao XH, Zheng LH, Jia YM, et al., 2025, Risk Factors for Malnutrition and Construction of a Risk Prediction Model in Lung Cancer Patients With Postoperative Chemotherapy. Journal of Translational Medicine, 14(4): 7–11.

Long MQ, Lai BY, Wang Y, et al., 2024, Incidence of Nosocomial Infection and Its Correlation With Mental Health Status in Patients With Acute Myeloid Leukemia Admitted to Laminar Flow Beds. Chinese General Practice Nursing, 22(15): 2952–2955.

Shi LX, Zhao MZ, Wang FF, et al., 2025, Clinical Analysis of Nutritional Components in Children With Acute Leukemia. Chinese Journal of Contemporary Pediatrics, 27(3): 300–307.

Zhu Y, 2023, Study on the Application Effect of Psychological Nursing Combined With Dietary Nursing in the Care of Leukemia Patients. China Food Industry, (18): 122–125.

Wang R, Huang J, Wan YY, et al., 2021, Investigation on Dietary Intake and Nutritional Status of Children With Acute Lymphoblastic Leukemia During Chemotherapy Induction Remission Period. Parenteral and Enteral Nutrition, 28(5): 281–285.

Liu LJ, Ding Y, Ye WH, 2022, Effect of Learning-Determined Teaching Diet and Nutrition Education on Nutritional Status and Quality of Life in Leukemia Patients Undergoing Chemotherapy. International Journal of Nursing, 41(15): 2764–2768.

Xing C, He X, Qin CW, 2024, Application Effect of Short-Peptide Enteral Nutrition Agent in Nutritional Support for Children With Leukemia. China Modern Medicine, 31(32): 66–69.

Wang J, Ren GL, 2021, Analysis of Influencing Factors of Peripherally Inserted Central Catheter-Related Venous Thromboembolism in Children With Acute Leukemia. Chinese Journal of Biomedical Engineering, 27(3): 288–293.

Zhang QM, Jiang HM, Zheng L, 2024, Application of Health Education Based on Behavior Change Model in Leukemia Patients Undergoing Chemotherapy. China Medical Herald, 21(3): 183–186.

Zhang HJ, Jin Y, 2024, Effect of Health Education Based on Behavior Change Model Combined With Psychological Intervention on Psychological Status and Compliance of Patients With Acute Leukemia Undergoing Chemotherapy. Oncology Progress, 22(23): 2592–2595.

Jiang L, Jiang Q, Miao PP, et al., 2024, Effect of Precision Nutrition Intervention on Nutritional Status and Chemotherapy Adverse Reactions in Patients With Prostate Cancer After Postoperative Chemotherapy. Oncology Progress, 22(11): 1247–1251.

Li Y, Feng C, 2023, Research Progress of Gut Microbiota Metabolites in Childhood Acute Myeloid Leukemia. Chinese Journal of Clinical Medicine, 51(10): 1154–1157.

Li XY, Xu LL, Ding J, 2025, Effects of Probiotics on Appetite Regulatory Factors, Intestinal Probiotics and Immune Status in Colorectal Cancer Patients Undergoing Chemotherapy. Sichuan Journal of Physiological Sciences, 47(5): 952–953 + 1015.

Sun H, 2022, Effect of the Integrated Doctor–Nurse–Dietitian Management Model on the Nutritional Status of Leukemia Patients Undergoing Chemotherapy. Modern Nurse (First Issue), 29(2): 108–111.

Gao QL, Chen C, Le SH, et al., 2021, Clinical Analysis of Pegaspargase-Associated Pancreatitis in Children With Acute Lymphoblastic Leukemia Undergoing Chemotherapy. Chinese Journal of Pediatric Hematology and Oncology, 26(5): 285–288 + 293.

Zhong LM, 2024, Effect of Multidisciplinary Team-Based Whole-Course Nutrition Management on Nutritional Status and Self-Care Ability of Esophageal Cancer Patients Undergoing Radiotherapy. Chinese General Practice Nursing, 22(9): 1713–1716.

Huang J, Hao PL, 2022, Investigation on Nutritional Status of Acute Leukemia Patients and Knowledge, Attitude, and Practice of Nursing Staff Towards Nutritional Management. Chinese Journal of Clinical Oncology Rehabilitation, 29(8): 945–949.

Previous article in this issue

Next article in this issue