Clinical Observation on the Curative Effect of Qingre Xiayi Decoction as Adjuvant Treatment for the Early Stage of Severe Acute Pancreatitis

³ Gongli Hospital of Pudong New Area, Shanghai 200135, China; Department of Gastroenterology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China,

PAR 2026 , 10(2), 144–155; https://doi.org/10.26689/par.v10i2.14547

© 2026 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objectives: To explore the clinical application value of Qingre Xiayi Decoction in the initial treatment of severe acute pancreatitis (SAP). Methods: A total of 60 patients with SAP were randomly divided into a control group and an observation group by the random number table method, with 30 cases in each group. The control group was treated with conventional Western medicine, while the observation group was treated with oral Qingre Xiayi Decoction on the basis of conventional Western medicine. The Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score, Visual Analogue Scale (VAS) score, time to abdominal pain relief, time for serum amylase to return to normal, TCM syndrome score, total treatment effective rate, and imaging changes were compared between the two groups before treatment and 3 days after treatment. Results: The total effective rate of the observation group (100%) was significantly higher than that of the control group (80%), and the difference was statistically significant (P < 0.05). After treatment, the APACHEⅡ score and VAS score of the observation group were lower than those of the control group, the time for serum amylase to return to normal and the time to abdominal pain relief were shorter than those of the control group, and the TCM syndrome score was also lower than that of the control group. All the above differences were statistically significant (P < 0.05). Imaging examination showed that the degree of improvement in the observation group was more obvious than that of the control group. Conclusion: Conventional Western medicine combined with Qingre Xiayi Decoction in the treatment of patients with initial SAP can significantly improve the therapeutic effect, relieve clinical symptoms and optimize related indicators, which is worthy of clinical promotion and application.

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