Objective: To investigate the level and influencing factors of benefit discovery in patients with breast cancer after operation. Methods: Convenient sampling method was used to evaluate the change of benefit discovery level of 60 patients with breast cancer after operation in a cancer ward of a hospital by using Chinese version of benefit discovery rating scale and general information questionnaire. Results: The level of benefit discovery of breast cancer patients at different stages was statistically different (P < 0.05). Age and education level entered the multiple linear stepwise regression equation of influencing factors of benefit discovery level of breast cancer patients (P < 0.05). Conclusion: Targeted nursing measures should be taken to improve the quality of life of patients with breast cancer.