Objective: To explore the anesthesia effect of ultrasound-guided nerve block in elderly patients with lower limb fractures. Methods: From November 2017 to November 2020, 50 elderly patients with lower limb fractures in our hospital were divided into experimental group (25 cases, general anesthesia + femoral nerve and sciatic nerve block) and control group (25 cases, general body anesthesia). Compare the MAP, HR, anesthesia effect, and adverse reactions between the two groups at each time period. Results: Before induction, the difference in MAP and HR between the two groups of patients did not form, p>0.05; the MAP and HR of the experimental group were compared with the control group at the time of skin incision, 1 hour during the operation, and removal of the laryngeal mask, P?0.05; the time of extubation in the experimental group (14.28±3.18) min, awake time (5.57±1.32) min, orientation recovery time (11.89±2.23) min, propofol dosage (191.36±22.48) mg, remifentanil dosage (0.23±0.04) mg, Compared with the control group, P<0.05; the adverse reaction rate of the experimental group (8%, 2/25) was lower than that of the control group (32%, 8/25), P<0.05. Conclusion: The use of ultrasound-guided femoral nerve and sciatic nerve block for elderly patients with lower limb fractures can enhance the effect of anesthesia, effectively reduce the use of anesthetics, and have fewer adverse reactions. It is worthy of promotion.