ARTICLE
Volume 10,Issue 4
20 May 2022
Research Progress in the Application of Lycium Barbarum Polysaccharide in Ophthalmic Diseases
Yanna Lin ,
Huiqin Wu
Show Less
1
Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China ,
2
Xi’an First Hospital, Xi’an 710000, Shaanxi Province, China,
PAR 2022 , 6(3), 17–22;
https://doi.org/10.26689/par.v6i3.3885
© 2022 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Lycium barbarum polysaccharides (LBP) are widely used in age-related macular degeneration, glaucoma, diabetic retinopathy, and other eye diseases. With further studies on the pharmacological action of Lycium barbarum polysaccharides in recent years, researchers have found that Lycium barbarum polysaccharides (LBP) play a protective role in the treatment of various eye diseases through anti-oxidation, scavenging oxygen free radicals, and inhibiting inflammatory reaction as well as cell senescence. This paper reviews the application of Lycium barbarum polysaccharides in ophthalmology.
References
Wang Y, An W, Shi Z, et al., 2008, Research Progress of Medicinal Value of Lycium Barbarum. Journal of Anhui Agricultural Sciences, 3008(30): 13213-13214, 13218.
Ma M, Zou D, Chen C, et al., 2021, Preparation and Pharmacological Action of Lycium Barbarum Polysaccharide. Qinghai Prataculture, 30(01): 38-42, 63.
Gao Y, Wei Y, Wang Y, et al., 2017, Lycium Barbarum: A Traditional Chinese Herb and a Promising Anti-Aging Agent. Aging and Disease, 8(6): 778.
Tian X, Liang T, Liu Y, et al., 2019, Extraction, Structural Characterization, and Biological Functions of Lycium Barbarum Polysaccharides: A Review. Biomolecules, 9(9): 389.
Wang Y, Jin H, Li Y, et al., 2021, Effects of Different Molecular Weight Lycium Barbarum Polysaccharides on Immune Regulation of RAW264.7 Macrophages. Chinese Journal of New Drugs, 30(12): 1079-1086.
Zhu J, Wu W, Ren S, et al., 2021, Effect of Aerobic Exercise Combined with Lycium LBP on the Inhibition of mTOR in H22 Hepatic Tumor in Mice. Chinese Journal of Cancer Prevention and Treatment, 28(05): 338-343.
Sun Q, Chen L, Chen S, 2021, Protective Effects of Lycium Barbarum Polysaccharide on Hydrogen Peroxide-Induced Neuronal Injury Through Nuclear Factor kB Signaling Pathway. Chinese Journal of Diabetes, 29(09): 692-699.
Ruíz-Salinas AK, Vazquez-Roque RA, Díaz A, et al., 2020, The Treatment of Goji Berry (Lycium Barbarum) Improves the Neuroplasticity of the Prefrontal Cortex and Hippocampus in Aged Rats. J Nutr Biochem, 83: 108416.
Simonyan KV, Avetisyan LG, Chavushyan VA, 2016, Goji Fruit (Lycium Barbarum) Protects Sciatic Nerve Function Against Crush Injury in a Model of Diabetic Stress. Pathophysiology, 23(3): 169-179.
Lin Y, Liu J, Su G, et al., 2019, The Neuroprotective Effect of Lycium Barbarum Polysaccharide (LBP): “Taking Eye as a Mirror”. China Journal of Ophthalmology of Traditional Chinese Medicine, 29(05): 403-406.
Zhang L, Peng K, Zhang B, et al., 2020, Research Progress of Lycium Barbarum Polysaccharide in the Repair of Peripheral Nerve Injury. Journal of Northwestern Medical University, 42(10): 959-960.
Zhang N, Tang FT, 2021, Study on Protective Effect and Mechanism of Lycium Barbarum Polysaccharide on Diabetic Kidney Injury. Chinese Journal of Clinical Pharmacology and Therapeutics, 26(11): 1237-1243.
He M, Pan H, Chang RC-C, et al., 2014, Activation of the Nrf2/HO-1 Antioxidant Pathway Contributes to the Protective Effects of Lycium Barbarum Polysaccharides in the Rodent Retina After Ischemia-Reperfusion-Induced Damage. PLOS ONE, 9(1): e84800.
Wang H, Dong Z, Guo L, et al., 2019, Effects of Lycium Barbarum Polysaccharide on the Expression of Caspase-3, Bcl-2 and Bax in Diabetic Rats. Chinese Journal of Gerontology, 39(20): 5070-5074.
Yao Q, Yang Y, Lu X, et al., 2018, Lycium Barbarum Polysaccharides Improve Retinopathy in Diabetic Sprague-Dawley Rats. Evid Based Complement Alternat Med, 2018: 7943212.
Liu L, Sha XY, Wu YN, et al., 2020, Lycium Barbarum Polysaccharides Protects Retinal Ganglion Cells Against Oxidative Stress Injury. Neural Regen Res, 15(8): 1526-1531.
Pan H, Shi Z, Yang T, et al., 2012, Protective Effects of Lycium Barbarum Polysaccharide on Retinal Neurons in Diabetic Rats and Its Mechanism. Chinese Journal of Applied Physiology, 35(01): 55-59.
Chan HH, Lam HI, Choi KY, et al., 2019, Delay of Cone Degeneration in Retinitis Pigmentosa Using a 12-Month Treatment with Lycium Barbarum Supplement. J Ethnopharmacol, 236: 336-344.
Liu F, Liu X, Zhou Y, et al., 2021, Wolfberry-Derived Zeaxanthin Dipalmitate Delays Retinal Degeneration in a Mouse Model of Retinitis Pigmentosa Through Modulating STAT3, CCL2 and MAPK Pathways. J Neurochem, 158(5): 1131-1150.
Zhu YF, 2016, Study on the Protective Effect of Lycium Barbarum Polysaccharide on N-Methyl-N-Nitrite Induced Retinitis Pigmentosa in Rats 32, Ningxia Medical University.
Xu X, Hang L, Huang B, et al., 2013, Efficacy of Ethanol Extract of Fructus Lycii and Its Constituents Lutein/Zeaxanthin in Protecting Retinal Pigment Epithelium Cells against Oxidative Stress: In Vivo and In Vitro Models of Age-Related Macular Degeneration. J Ophthalmol, 2013: 862806.
Liang R, Zhao Q, Zhu Q, et al., 2021, Lycium Barbarum Polysaccharide Protects ARPE?19 Cells Against H(2)O(2)?Induced Oxidative Stress Via the Nrf2/HO?1 Pathway. Mol Med Rep, 24(5): 769.
Gao Y, 2021, Study on the Effect of Autophagy on Light Damage of Human Retinal Pigment Epithelial Cells and the Intervention Effect of Lycium Barbarum Polysaccharide Based on PI3K/Akt/mTOR Signaling Pathway, Ningxia Medical University.
Yao Q, Zhou Y, Yang Y, et al., 2020, Activation of Sirtuin1 by Lyceum Barbarum Polysaccharides in Protection Against Diabetic Cataract. J Ethnopharmacol, 261: 113165.
Chien KJ, Horng CT, Huang YS, et al., 2018, Effects of Lycium Barbarum (Goji Berry) on Dry Eye Disease in Rats. Mol Med Rep, 17(1): 809-818.
Wang Y, Xiao J, Duan Y, et al., 2021, Lycium Barbarum Polysaccharide Ameliorates Sjogren’s Syndrome in a Murine Model. Mol Nutr Food Res, 65(11): e2001118.
Lakshmanan Y, Wong FSY, Zuo B, et al., 2019, Posttreatment Intervention with Lycium Barbarum Polysaccharides is Neuroprotective in a Rat Model of Chronic Ocular Hypertension. Invest Ophthalmol Vis Sci, 60(14): 4606-4618.
Share
Back to top
Bio-Byword Scientific Publishing Pty. Ltd.
We are committed to supporting the scientific community by publishing impactful research and fostering effective communication among scientists. We continuously seek ways to accelerate scientific progress while upholding transparency and open dialogue. Our goal is to make knowledge freely and barrier‑free accessible to all.
Contact us: info@bbwpublisher.com
Level 10, 50 Clarence Street Sydney, NSW 2000 Australia