ARTICLE
Volume 10,Issue 4
29 March 2023
A Proposed Solution to the Interference of IgG Kappa-Type M Protein on LDL-C Detection
Chao Yang ,
Yang Yu ,
Shuxin Liang ,
Haige Zhao ,
Na An
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1
Department of Laboratory Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,
2
Department of Laboratory Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,
3
Department of Laboratory Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,
4
Department of Laboratory Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,
5
Department of Laboratory Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,
PAR 2023 , 7(2), 1–5;
https://doi.org/10.26689/par.v7i2.4736
© 2023 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Objective: To explore the interference of monoclonal immunoglobulin (M protein) on the detection of serum LDL-C in patients with multiple myeloma, improve the understanding of this matter, determine and establish the correct method, and provide more accurate clinical results through this case. Methods: A case was selected for analysis by the direct method. Results: The interference of IgG kappa-type M protein on LDL-C detection could not be completely eliminated by the enzymatic method. Conclusion: IgG-type type M protein affects the detection of LDL-C by the enzymatic method; thus, light reagents can be used with the direct method for detection.
References
Zhang Y, Liu F, Tian H, et al., 2021, Clinical Significance of M Protein Concentration Detection in Patients with Monoclonal Immunoglobulinemia. Journal of Nephrology and Dialysis Kidney Transplantation, 30(2): 130–35.
Zhuang Y, 2020, Observation on the Effect of Hemolysis and Lipidemia in Serum Samples on the Results of Biochemical Tests. Clinical Research, 18(2): 112–113.
He J, Wang Z, Hu Y, 2013, Interference of IgM M Protein on Clinical Biochemical Detection. Chinese Medicine Guide, 11(15): 432–434.
Li J, Wang L, Zhao X, et al., 2011, Interference and Analysis of Rare IgA M Protein to Clinical Chemical Detection. Marker Immunoassay and Clinical Analysis, 18(6): 398–402.
King RI, Florkowski CM, 2010, How Paraproteins Can Affect Laboratory Assays: Spurious Results and Biological Effects. Pathology, 42: 397–401.
Yang Y, Howanitz PJ, Howanitz JH, et al., 2008, Paraproteins Are a Common Cause of Interferences with Automated Chemistry Methods. Archives of Pathology & Laboratory Medicine, 132(2): 217–223.
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