Objective: To investigate the clinical application effect of laparoscopic-assisted total gastrectomy in the surgical treatment of gastric cancer. Methods: The clinical data of 86 COPD patients included in the study were collected and divided into 43 cases each in Groups A and B using the randomization method, with open total gastrectomy in Group A and laparoscopic-assisted total gastrectomy in Group B. The clinical indexes, pain levels, and complications of patients in the two groups were observed in combination with the indexes. Results: The baseline data of the two groups of patients were not statistically significant (all P > 0.05); the operation time, incision length, first flatulence time, and hospitalization time of patients in Group B were shorter than those in Group A (all P = 0.000); the NRS scores of patients in Group B on the 1st postoperative day and the 2nd postoperative day were significantly lower than those in Group A (t = 23.443, t = 28.784, all P =  0.000); the total complication rate of patients in Group B (1; 2.33%) was significantly lower than that of Group A (9; 20.94%) (χ² = 7.242, P = 0.007). Conclusion: In the surgical treatment of gastric cancer, laparoscopic-assisted total gastrectomy can promote patients’ recovery, reduce patients’ pain, and lower the probability of complications.