Clinical Efficacy of Laparoscopic Radical Colorectal Cancer Treatment for Colorectal Cancer and Its Effect on Immune Function

© 2024 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Objective: To explore the therapeutic effect of laparoscopic radical colorectal cancer treatment in colorectal cancer patients. Methods: A total of 50 colorectal cancer patients treated between August 2018 and August 2023 were randomly divided into two groups: Group A underwent laparoscopic radical colorectal cancer surgery, while Group B received open surgery. Clinical indicators, inflammatory factors, immune function indicators, and complications were compared between the two groups. Results: Group A showed significantly shorter operation times, faster recovery times, and reduced hospital stays compared to Group B. Additionally, Group A had less abdominal drainage and intraoperative bleeding (P < 0.05). Levels of interleukin (IL)-4, IL-6, ultrasensitive C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-α) were lower in Group A compared to Group B (P < 0.05). Furthermore, immune function indicators, including CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ ratios, were better in Group A (P < 0.05). The complication rate in Group A was also lower than in Group B (P < 0.05). Conclusion: Laparoscopic radical treatment for colorectal cancer is efficient and feasible, causing minimal immune function impairment and inflammatory response. It also shortens postoperative recovery time.

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