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Volume 10,Issue 4

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29 May 2025
Observation on the Effect of Interventional Therapy Combined with Lenvatinib and Sintilimab in the Treatment of Advanced Liver Cancer
Yana Gao ,  Jiao He ,  Qiliang Xu
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1 School of Clinical Medicine, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, Hubei, China,
2 Xianning Central Hospital, Xianning 437000, Hubei, China,
PAR 2025 , 9(3), 69–74; https://doi.org/10.26689/par.v9i3.10525
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Objective: To observe the control effect of interventional therapy combined with lenvatinib and sintilimab in patients with intermediate and advanced liver cancer. Methods: 82 patients with intermediate and advanced liver cancer who visited from January 2022 to January 2025 were selected as samples and randomly divided into two groups. Group A received interventional therapy combined with lenvatinib and sintilimab, while Group B received interventional therapy combined with lenvatinib. Disease remission rate, adverse reactions, liver function indicators, and tumor marker indicators were compared between the two groups. Results: The disease control rate (DCR) in Group A was higher than that in Group B (P < 0.05). There was no difference in adverse reaction rates between Group A and Group B (P > 0.05). Total bilirubin (TBil), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in Group A were lower than those in Group B (P < 0.05). Carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and alpha-L-fucosidase (AFU) levels in Group A were also lower than those in Group B (P < 0.05). Conclusion: Intermediate and advanced liver cancer patients receiving interventional therapy combined with lenvatinib and sintilimab showed reduced tumor marker levels, lessened liver function damage, and a high disease control rate and treatment safety.

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