ARTICLE
Volume 10,Issue 4
7 August 2025
Research Progress of HER-2 in Colorectal Cancer
Dongmei Xie ,
Yanfei Pan ,
Siwen Wan
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The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, Guangxi Zhuang Autonomous Region, China,
PAR 2025 , 9(4), 106–113;
https://doi.org/10.26689/par.v9i4.11556
© 2025 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract
Human epidermal growth factor receptor 2 (HER-2) is a transmembrane receptor tyrosine kinase that is overexpressed in various solid tumors and is closely related to tumor invasion, metastasis, and poor prognosis. In recent years, the expression of HER-2 in colorectal cancer and its clinical significance have gradually attracted attention. This article reviews the expression of HER-2 in colorectal cancer, the clinicopathological characteristics of HER-2 positive colorectal cancer, the detection methods of HER-2, and the drug treatment targeting HER-2, to provide references for clinical diagnosis and treatment and research.
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