With the comprehensive development of modern information technology, big data technology has been integrated into various industries and has become a pillar technology supporting industrial upgrading and transformation. In enterprise human resource management, big data technology also has a broad application space and important application value. To gain higher market competitiveness and comprehensively improve the quality and efficiency of human resource management, enterprises need to rely on big data technology for comprehensive reform and optimization, thereby building an efficient, fair, open, and scientific human resource management model. This paper analyzes the problems and changes of enterprise human resource management in the era of big data, and then puts forward effective strategies for enterprise human resource management based on the era of big data.