The purpose of this article is to comprehensively analyze the phenomenon of deconstruction and reinvention in the remake process of the film Infernal Affairs (2002) and its Hollywood remake The Departed (2006) from a cross-cultural perspective. With the continuous advancement of globalization, the film is an important carrier of cultural communication, so its cross-cultural remake has become an important bridge connecting different cultures. Hollywood, as the leader of the global film industry, has not only maintained the vitality of the industry through the remake strategy but also successfully absorbed the cultural creativity of Asian countries. Taking The Departed and Infernal Affairs as examples, this paper explores in detail the differences in cultural positioning, the shift in narrative purpose, the similarities and differences in characterization, as well as the use of visual styles and the aesthetics of violence in the remakes of the two films. The study finds that Hollywood has profoundly deconstructed the Chinese cultural elements in the original film during the remake process, and reconstructed a narrative system in line with the American cultural background, thus realizing cultural reconstruction and dissemination. This process not only reflects the influence of cultural differences on film creation but also reveals the complexity of cultural infiltration in the context of globalization.