Under the background of the new era, the in-depth integration of party building and business work in grassroots party organizations of colleges and universities is an important proposition to implement the fundamental task of fostering morality and cultivating people and promote the high-quality development of higher education. Taking grassroots party branches of colleges and universities as the research object, this paper addresses practical problems such as "superficial integration" and "insufficient mechanism coordination" between party building and business. Based on the "Point-Line-Surface-Body" collaborative innovation framework, it constructs a four-dimensional integration model of "Point—Precise connection with curriculum ideological and political education, Line—Branch-led geese formation effect, Surface—Professional construction community, Body—Department collaborative ecology", exploring the practical path of in-depth integration of party building and business. It provides practical reference for solving the dilemma of "two skins" between party building and business in colleges and universities.