Guizhou Province has become an important tourist destination for domestic and foreign tourists because of its unique karst landscape, colorful folklore, and suitable weather. In the face of fierce competition in the domestic and international tourism markets, this paper proposes a series of countermeasures to enhance the competitiveness of Guizhou’s tourism industry, including optimizing the socio-economy, improving the competitiveness of resources, exploring the potential to improve the socio-economic benefits, and making use of the natural advantages to create an “ecological” Guizhou, and so on. These measures aim to promote the leapfrog of Guizhou’s tourism industry and enhance its competitiveness in the tourism market through policy guidance, capital investment, talent training, digital transformation, ecological protection, and cultural heritage.