With the in-depth development of education informatization and the improvement of students’ comprehensive English ability, college English writing teaching needs an innovative mode to meet the new needs. College English writing teaching is the core link of cultivating students’ comprehensive language ability, and its quality is directly related to students’ cross-cultural communication level and future development. However, the traditional teaching methods have been difficult to meet the current teaching needs. The combination of content language integration teaching (CLIL) and blended teaching mode has brought new opportunities for college English writing teaching. This innovative teaching mode can effectively integrate students’ language knowledge and practical application, and enhance their comprehensive language application ability. This paper elaborates on the theory of content language integration (CLIL) and blended teaching, deeply discusses the advantages of college English writing blended teaching under the concept of content language integration, and puts forward the implementation strategy of college English writing blended teaching under the concept of content language integration, aiming to provide theoretical and practical reference for improving the quality of college English writing teaching and cultivating high-quality English talents to meet the needs of the times.