Against the backdrop of the Belt and Road Initiative, overseas thermal power enterprises face challenges such as complex geographical environments, difficult safety supervision, and prominent localized management issues. Huadian Xigang Power Generation Co., Ltd. (Cambodia) has constructed an intelligent safety prevention and control system with global perception as the core based on industrial Internet and artificial intelligence technologies. This paper elaborates on the architectural design, key technology applications, and practical effects of the system. Through innovative means such as 3D digital twin, AI intelligent patrol, and multi-system integration, it realizes the upgrade of safety management in overseas power plants from passive response to active prevention and control, providing a reproducible technical paradigm and management experience for safety governance of energy enterprises along the Belt and Road.