This paper focuses on the creative transformation strategy of traditional cultural genes in the central plains region. Firstly, the paper elaborates on the roots and originality of the excellent traditional culture of the central plains, and analyzes the advantages and optimization problems in the development of its cultural industry. Then, it puts forward a new transformation idea of rearranging and combining cultural resources, and gives the strategies, such as systematically integrating traditional culture resources, symbolizing and re-innovating culture, creating cultural name cards with the help of branding, and integrating modern aesthetics to realize the modern expression of traditional culture. The research strategy helps to enhance the competitiveness of the cultural industry in the central plains, promotes the inheritance and translation of traditional culture, injects a new impetus for regional economic development, and at the same time provides a sample of the central plains for the global dissemination of Chinese culture.