Under the background of the “hundred million project” in Guangdong Province, the activation of sleeping resources in the Guangdong-Hong Kong-Macao Bay area has become an important issue to promote regional coordinated development. This paper sorts out the current situation and activation practice of Dawan district’s sleeping resources such as culture, human resources, land and industry, and analyzes the current challenges such as talent shortage, weak cultural heritage, and lack of infrastructure, combined with typical cases such as Tangjiawan in Zhuhai, Dongfeng in Zhongshan, and Huidong in Huizhou, and then puts forward the activation paths such as the talent strategy of “combining education with introduction”, “intangible cultural heritage+tourism” integration path, infrastructure optimization, and industrial collaborative innovation. The research shows that the value transformation of sleeping resources can be realized through the coordination of multiple subjects and mechanism innovation, which provides a reference for the high-quality development and Rural Revitalization of the Guangdong-Hong Kong-Macao Greater Bay area.