Efficacy of Yishen Tongluo Formula Combined with Sulodexide in the Treatment of Diabetic Nephropathy with Renal Failure

¹ Department of Nephrology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding 071000, Hebei Province, China,

² Department of Combined Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China,

UR 2024 , 2(4), 1–6; https://doi.org/10.26689/ur.v2i4.9318

© 2024 by the Authors. Licensee Whioce Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

Abstract

Objective: To analyze the effect of Yishen Tongluo Formula combined with sulodexide in treating patients with diabetic nephropathy and renal failure. Methods: A hundred patients with diabetic nephropathy accompanied by renal failure who were admitted to the hospital for treatment from March 2021 to March 2024 were randomly divided into the control group and the observation group, and were treated with sulodexide therapy and Yishen Tongluo Formula + sulodexide therapy, respectively. The treatment efficacy of the two groups was evaluated. Results: After treatment, fasting blood glucose and other levels were lower in the observation group, P < 0.05; renal function indexes in the observation group improved, where levels of 24-hour urinary protein, blood urea nitrogen, and blood creatinine were significantly lower than those of the pre-treatment and control group; the effect of microinflammatory state relief was significant, as demonstrated by the significant decrease of interleukin-6 and other indexes, P < 0.05. Conclusion: In the treatment of diabetic nephropathy patients with renal failure, we should pay attention to the protection of renal function, applying sulodexide to improve patients’ blood glucose indexes, and at the same time, utilizing Yishen Tongluo Formula to alleviate patients’ microinflammatory state and enhance the recovery of renal function.

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