Objective: To analyze risk factors for urethral stricture and preventive nursing strategies following transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH). Methods: Clinical data of 266 BPH patients undergoing TURP in our hospital’s Department of Urology from June 2020 to May 2023 were retrospectively analyzed. Postoperative urethral stricture incidence was observed and recorded, with multivariate logistic regression analysis applied to identify risk factors. Results: Among 266 BPH patients undergoing TURP, 21 developed urethral strictures (incidence rate: 7.89%). Multivariate logistic regression analysis revealed that a history of diabetes mellitus, preoperative urethral infection, Grade III prostate volume, operative time ≥ 70 min, urinary catheterization duration ≥ 5 days, and intraoperative urethral dilation and reconstruction were independent risk factors for urethral stricture following TURP in BPH patients. Conclusion: Multiple risk factors contribute to urethral stricture following transurethral resection of the prostate in patients with benign prostatic hyperplasia. Implementing safe and effective preventive measures is essential to control these risks and improve patient outcomes.